Lee [21] et al. prepared nanoparticles formed by the chemical coupling of the hydrophobic portion of hyaluronic acid with hydrophobic lithocholic acid, which could accumulate and target pro-inflammatory macrophages in the inflamed dermis after transdermal administration, thereby ameliorating the epidermal proliferation and pro-inflammatory response in a mouse model of psoriasis-like skin dermatitis induced by imiquimod and interleukin 23. This evidence concerns the gene IL37 and psoriasis.