Research indicates that L-peptide-coated PTX-loaded nanoparticles (L-CS-g-PNIPAM-PTX) exhibit enhanced specificity and anti-proliferative effects in MDA-MB-231 cells (GRP78+), leading to an extended median survival time in breast cancer-bearing mice with complete inhibition of tumor growth [49]. Here, HSPA5 is linked to breast carcinoma.