ACE2 and pulmonary hypertension: Previously, we reported the codon optimization of both human genes ACE2 and Ang(1–7), the generation of transplastomic lines, biomass optimization, and the evaluation of the potency in the treatment of pulmonary hypertension upon oral delivery [32,33] or in trapping SARS-CoV-2 upon the topical delivery of ACE2 [12,19].