NFKB1 and osteosarcoma: While in breast cancer cells MDA-MB-231, MCF-7, and BT-20, and lung carcinoma and osteosarcoma cell lines, it was demonstrated that DMDD induces sustained ROS overproduction leads to inhibition of the cell cycle transition from G1 to the S phase, apoptosis, and canonical NF-κB pathway inhibition [30].