GSR and obesity due to melanocortin 4 receptor deficiency: This extract helped maintain levels of reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT), all important antioxidant factors in the liver, which would normally be reduced due to oxidative stress caused by obesity and a high-fat diet.