TYR and Hyperglycemia: NADES 14 (ChCl/lactic acid/water 1:2:5) showed the strongest tyrosinase inhibition, suggesting its potential for skin-brightening applications, while NADES 13 and 15 (ChCl/citric acid/water 1:2:3 and 1:1:5, respectively) and NADES 14 exhibited significant α-amylase inhibition, surpassing the reference compound acarbose, and indicating the potential for managing hyperglycemia.