The HLA-DRB1/DQA1 locus was more prevalent (p = 2.07 × 10−5) in multiplex-affected families (n = 444) with at least two relatives with generalized vitiligo compared to simplex cases with no family history of vitiligo, suggesting that HLA-related adaptive immune responses may be especially important to vitiligo pathobiology in multiplex-affected families [42]. This evidence concerns the gene HLA-DRB1 and vitiligo.