Likewise, several meta-analyses have evidenced the ability of exercise training to induce a moderate, time&dose-response increase in adiponectin, as well as the reduction of leptin, IL-8, and favorable body mass changes, thereby promoting anti-inflammatory effects, insulin sensitivity, and enhancement of cardio-metabolic health, where individuals with obesity often show more significant changes [19,31,32,33,34]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.