MPO and hypertensive disorder: Naïve patients with essential hypertension (EHT, n = 55) displayed higher levels of NETs in plasma (determined as MPO/DNA complexes and citH3 by ELISA methods) compared with their normotensive peers (n = 26), and plasma samples from untreated EH patients primed neutrophils isolated from healthy individuals to form NETs in an ROS and histone citrullination-dependent manner [157].