Metformin reduced tumor growth, probably via improving elevated glycemia, insulinemia, soluble P-selectin, TGF-β1, HMGB1, and tumor expression of malignance-associated signaling molecules, such as those promoting proliferation, and aerobic glycolysis-, glutaminolysis-, platelets-, and neutrophils-associated molecules. This evidence concerns the gene TGFB1 and neoplasm.