Bioinformatics and proteomics analyses suggested that IL-8 (a macrophage-derived protein triggering rapid migration of neutrophils), heat shock protein 90 (HSP90, molecular chaperon potentially promoting inflammation and thus activating NETs signaling pathways in obesity), and the E1 heat shock protein family HSPE1 (the cochaperone for HSP 60 inhibiting the inflammatory response) could modulate NETs formation in obesity [100]. The gene discussed is HSPE1; the disease is obesity due to melanocortin 4 receptor deficiency.