Among gut epithelial cells are the intraepithelial lymphocytes (IELs) [27], which are predominantly composed of TCRαβ+ CD8+ T cells with an effector memory phenotype in non-inflammatory conditions; conversely, during active CeD, TCRγδ+ T cells increase notably in the context of IELs, even with expression of NK cell receptors [28], such as activating NKG2D and CD94/NKG2C [29]. Here, KLRD1 is linked to cranioectodermal dysplasia.