The pro-inflammatory cytokines IL-1, IL-6, and TNF-α, which are increased in the serum of CeD patients, are known to be involved in the enhanced expression of receptor activator of nuclear factor kappa-B ligand (RANKL), its binding with RANK on osteoclast precursors, and the inhibition of osteoprotegerin (OPG). The gene discussed is TNFRSF11B; the disease is cranioectodermal dysplasia.