This is of particular interest because they can turn nearly ubiquitous, and recent research has addressed these plants as anti-neuroinflammatory, affecting NF-κB signaling and pro-inflammatory cytokines production, including prostaglandins and leukotrienes, therefore, suppressing or delaying their onset NDs and fighting against depression, anxiety, stroke, and even CNS infections [184]. Here, NFKB1 is linked to major depressive disorder.