Through the activation of the JAK/STAT pathway, the polarization of pro-inflammatory macrophages becomes possible, having an intrinsic relationship with Interferon-Gamma (IFN-γ), so that a deficiency in this interferon, presented by mice, demonstrated a reduction in the amount of neuron loss present in the substantia nigra through the induction of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP), which is also related to the Parkinson’s Disease [138]. This evidence concerns the gene SOAT1 and Parkinson disease.