SNAI1 and neoplasm: In the research conducted on breast tumours, it has been proven that histologically normal tissue adjacent the visible margin of the lesion at a 1 cm distance displayed higher levels of gene transcripts, such as IGF1, platelet-derived growth factor receptor β (PDGFRB), TGF-β3, SNAIL, or vimentin, than tissue surrounding the tumours at the distance of 5 cm, which suggested that EMT-related events occur even in a seemingly healthy, neighbouring area [49].