OPRM1 and hepatocellular carcinoma: Furthermore, HCC MHCC-97H cells with silenced MOR expression demonstrated downregulation of vimentin, N-cadherin, TWIST, and SNAIL, but upregulation of E-cadherin, while another HCC cell line, HepG2, engineered to overexpress MORs, displayed the opposite expression pattern of these EMT-related proteins [70].