VIM and lung carcinoma: On the contrary, another MOR agonist, sufentanil, being a derivative of potent opioid agonist fentanyl, decreased invasion and migration of human H460 and H1299 lung cancer cells, which was reflected at the molecular level by upregulation of ZO-1 typically present in tight junctions, changes in cadherins and vimentin levels specific for EMT withdrawal, and downregulation of WNT signalling pathway molecules: β-catenin, MYC, and MMPs [42], (Table 2).