In the present work, the synthesis of phenstatin-letrozole hybrid compounds is now extended to include heterocyclic modifications of chalcones with the synthesis novel hybrid (E)-1-(1,3-diphenylallyl)-1H-1,2,4-triazoles and related compounds as dual aromatase-tubulin targeting compounds with activity in breast cancer. This evidence concerns the gene CYP19A1 and breast carcinoma.