The results indicated that WLD administration significantly reduced the levels of the Th1-associated cytokine IFN-γ and Th17-associated cytokines (TNF-α, IL-17, IL-21, and IL-23), while it significantly elevated the levels of the Th2-related cytokine IL-4 and Treg-associated cytokines (IL-10 and TGF-β1) in the CDD group (p < 0.01). The gene discussed is IL21; the disease is craniodiaphyseal dysplasia.