Betulin has been demonstrated to exert a beneficial effect in the context of 7,12-dimethylbenz(a)anthracene-induced rat mammary cancer, with its action involving the modulation of the mitogen-activated protein kinase (MAPK) and aryl hydrocarbon receptor/nuclear factor erythroid 2-related factor (AhR/Nrf-2) signaling pathways [11]. This evidence concerns the gene NFE2L2 and breast cancer.