The results indicated that CCLE significantly downregulates IL-6 (p < 0.0001, Figure 3A), TNF-α (p < 0.01, Figure 3B), IL-1β (p < 0.05, Figure 3C), and MPO (p < 0.001, Figure 3D) in DSS-induced IBD mice. Here, TNF is linked to inflammatory bowel disease.