The overexpression of Hsps such as Hsp27, Hsp70, Hsp90, Grp78 and Grp94 was associated with hepatocarcinogenesis, while increased levels of Hsp90, Grp78 and Grp94 were connected with HCC metastasis and vascular invasion [33]. This evidence concerns the gene HSP90B1 and hepatocellular carcinoma.