AKT1 and hepatocellular carcinoma: Several natural chalcones were reported to have potent anti-HCC activities including apoptosis induction (xanthohumol, butein and cardamonin), interference with vital oncogenic signaling pathways (Notch signaling by xanthohumol, Akt signaling by isoliquiritigenin) and protein kinases (EGFR and aurora B kinase by butein), and inhibition of migration and invasion (licochalcone A and xanthohumol, Figure 1) [16,17,18,19,20,21,22].