To shed new light on the pathogenesis of GDM, Han et al. [67] investigated the expression of SIRT1, sterol regulatory element-binding protein-1 (SREBP1), and pyroptosis factors, including NLRP3, caspase-1, IL-1β, and IL-18 in placental tissue and sera of GDM patients (Table 1). Here, NLRP3 is linked to gestational diabetes.