Elevated levels of adenosine deaminase (ADA), gamma-glutamyl transferase (GGT), ecto-5′-nucleotidase (CD73), and lactate dehydrogenase (LDH) in the AOM-treated group (G2) were substantially reduced by MEA treatment, particularly in the high-dose group (G4). The gene discussed is NT5E; the disease is infectious otitis media.