IFNG and idiopathic generalized epilepsy: Finally, Wang, Wang [113] found that in three distinct types of epilepsy, namely temporal lobe epilepsy (TLE), extra-temporal lobe epilepsy (XLE), and idiopathic generalized epilepsy (IGE), only four independent cytokine biomarkers (IL-6, IFN-γ, IL-17-a, and IFN-λ3) are correlated with severe seizures.