TNF and gout: To investigate the effects of the Terpinen-4-ol on gouty arthritis, the target genes of Terpinen-4-ol network and the ‘gout’ gene set were compared, resulting in the deduction of eight intersecting genes, including NLRP3, PTGS2, CXCL8, IL6, TNF, IL1B, TLR4, and ALB (Figure 3C).