TNF and gout: Based on significant FDR values, the potential functional mechanisms of ZP on gouty arthritis were mainly associated with the ‘NOD-like receptor signaling pathway (hsa04621)’, ‘NF-kappa B signaling pathway (hsa04064)’, ‘Toll-like receptor signaling pathway (hsa04620)’, ‘TNF signaling pathway (hsa04668)’, and ‘Cytokine–cytokine receptor interaction (hsa04060)’ on the KEGG Pathways database (Figure 4A).