RPIA and Cowden disease: Owing to the still obscure pathology of CD, the target-based search for new potential antichagasic drugs has been limited; despite this, some recent efforts were also focused on parasite enzymes [74], such as enolase [75], cruzain [76], ribose-5-phosphate isomerase (RPI) [77,78], isocitrate dehydrogenase (IDH2) [79], sirtuins [80,81,82], and sterol 14α-demethylase (CYP51) [83,84,85].