AKT1 and breast neoplasm: The researchers noted that the combined treatment of cimetidine and vitamin C, in particular, was responsible for the reduction in histamine in the tumor microenvironment, and they proposed that such a treatment, by reducing histamine levels, may reduce the activity of the PI3K/AKT/mTOR signaling pathway, which is related to the survival of breast tumor cells, with the consequent inhibition of tumor progression [56].