GPT and hepatitis D virus infection: Recent WHO CHB new treatment guidelines recommend the treatment of CHB cases with (i) evidence of significant fibrosis, (ii) HBV DNA >2000 IU/mL and an ALT level above the upper limit of normal, (iii) the presence of coinfections (such as HIV, hepatitis D, or hepatitis C), and (iv) those with persistently abnormal ALT levels.