Additionally, through the Fap2 adhesin, Fn interacts with pancreatic cancer cells, promoting Fn infection in pancreatic cancer by causing infected tumor cells to release cytokines such as GM-CSF, CXCL1, IL-8, and MIP-3α, thereby promoting further tumor progression (Figure 2). This evidence concerns the gene CXCL8 and familial pancreatic carcinoma.