Notably, in the dominant model, we observed a statistically significant association between IL-1β SNP and the presence of all three studied conditions; a patient carrying at least one IL-1β rs16944 allele [T] was approximately three times more likely to have AD, AF, and anaphylaxis simultaneously (OR = 2.89; 95% CI 1.18 ÷ 7.08; p = 0.031) compared with the wild-type homozygote. The gene discussed is IL1B; the disease is atrial fibrillation.