Comparing migraine with other types of headache in MS (tension type and post-interferon beta treatment), Villani et al. found that pwMS with migraine had a higher frequency of days with headache per month (mean of 9.1 vs. 3.3 of tension type of headache) and a greater level of migraine disability at HIT-6 scores than pwMS with other types of headache (mean of 51.6 vs. 37.7 of tension type of headache) [15]. This evidence concerns the gene IFNB1 and Tension-type headache.