NLR and NPR were characterized by high specificity in the initial diagnosis of CIED infections, with optimal cutoff values of 3.06 and 0.02, compared to CRP; NLR was also shown to be useful in the assessment of the spread of infection in patients with PI, with an optimal cutoff value of 3.13, while NPR may be helpful in the differentiation between vegetation and vegetation-like masses with an optimal cutoff value of 0.03 [28]. The gene discussed is NPTXR; the disease is infection.