In contrast, the downregulation of HLA-DRA, HLA-A, HLA-B, and HLA-C, which are components of the MHC antigen presentation machinery, suggests a disruption in antigen presentation pathways, further hindering the immune system’s ability to recognize and eliminate tumor cells (Figure 3C and Supplementary Figure S2B). The gene discussed is HLA-DRA; the disease is neoplasm.