Rowe et al. [23], in a retrospective analysis, explored the correlation between MSI, Wnt/β-catenin pathway activation, and PD-L1 expression, considering Lynch-syndrome-associated carcinomas (23 cases), MLH1 promoter hypermethylated carcinomas (20 cases), and pMMR/MSS carcinomas. The gene discussed is MLH1; the disease is carcinoma.