Unlike hypothyroidism and pneumonia, a significant increase in the rates of hepatitis (17.3% vs. 5.8%; p = 0.002) and cardiovascular complications (4.9% vs. 0.3%; p = 0.005) was observed in the anti-PD-L1 compared to the anti-PD1 group in our study. This evidence concerns the gene PDCD1 and hypothyroidism.