At the age of 35, HLAB27-positive ankylosing spondylitis was diagnosed, and the patient was promptly treated with infliximab, due to the lack of response and poor tolerance to nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 inhibitors (Coxibs). The gene discussed is PTGS2; the disease is ankylosing spondylitis.