CD4 and cancer: Cluster #22398, which was prevalent in COP (COP vs. malignancies: 11.9 ± 0.6% vs. 1.7 ± 0.9%), was characterized by the expression of CD4+ CD16+ HLA-DR+ CD44hi ST2+ TIM-3hi PD-L1hi PD-L2hi (Figure 4B,C).