HIF-PHIs can be considered in patients with DD CKD receiving HD when the patient prefers an oral treatment, the patient is receiving HD at home, there is a hypersensitivity/unavailability of intravenous iron, the patient experiences ESA hyporesponsiveness or intolerance, and there is a chronic inflammatory state (CRP levels ≥3 mg/L) [36]. The gene discussed is CRP; the disease is chronic kidney disease.