GHRL and obesity due to melanocortin 4 receptor deficiency: Bhargava et al. found that an increase in postprandial plasma LEAP-2 of humans without obesity was involved in the homeostasis of the body energy balance by promoting a decrease in postprandial appetite and food intake, as well as correlated negatively with body mass index (BMI), although no significant trends were observed for the plasma acyl-ghrelin or LEAP-2/acyl-ghrelin molar ratio [54].