Moreover, the in vitro activation of the cannabinoid receptor 1 (CB1) on macrophages in colorectal cancer indicated the suppression of M2 macrophage polarization and decreased the proliferation, migration, and invasion of the tested human colorectal cancer cell lines, while silencing of CB1 promoted M2 polarization and cancer cell proliferation [139]. The gene discussed is CNR1; the disease is colorectal cancer.