SLC7A11 and neoplasm: The different extents of ferroptosis observed in wt- and mutp53 cells may be due to the fact that, unlike wtp53, mutp53 is unable to repress function and can even upregulate the cystine/glutamate transporter SLC7A11, which increases the capacity of tumor cells to resist ferroptosis by increasing glutathione-mediated anti-oxidant defense [26].