Among them, matrix metalloproteinase-1 (MMP-1), a calcium- and zinc-dependent vertebrate collagenase subclass, is a member of the MMP family capable of efficiently degrading type I and type III interstitial collagen, which is involved in a wide range of physiological and pathological processes, including tumors, cardiovascular diseases, multiple sclerosis, and skin aging. The gene discussed is MMP1; the disease is cardiovascular disorder.