In addition, tangeretin (25, 50, and 100 μM) significantly inhibited cancer cell viability and induced DNA fragmentation and apoptosis by increasing the expression of caspase-3 and pro-apoptotic proteins (Bad and Bax) and by decreasing the expression of anti-apoptotic proteins (Bcl-2 and Bcl-xL) [47]. Here, CASP3 is linked to cancer.