Because the JAK/STAT-3 pathway plays a key role in the development and survival of various cancer cells, abnormal JAK/STAT-3 signaling can lead to tumor metastasis, and tangeretin can reduce the expression of the p-JAK, JAK, p-STAT-3, and STAT-3 proteins while simultaneously inhibiting the growth and survival of cancer cells. The gene discussed is STAT3; the disease is cancer.