Other researchers have used bioinformatic methods to study the inhibition of PTs and mechanisms in metastatic breast cancer, as well as the important role of the PI3K/Akt pathway and related genes (TP53, PTGS2, NFKB1, and PIK3CA) in the anti-metastasis effect of tangeretin on metastatic breast cancer cells [41]. This evidence concerns the gene PIK3CA and breast carcinoma.