TNFRSF10A and cancer: The downregulation or deletion of the expression of death receptors DR4 and DR5 is the main mechanism of TRAIL resistance, and tangerine can upregulate the expression of DR4 and DR5 and downregulate the expression of DcR1 and DcR2 (TRAIL antagonistic decoy receptor); therefore, the combination of tangerine and TRAIL can significantly increase the apoptosis of cancer cells.