GPT and injury: Based on these findings, rats fed a diet containing 0.5 g/kg CA, which mimics the increased release of 12OH bile acids into the gut due to a high-fat diet, exhibited an elevation of blood pressure [18], an increase in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (markers of liver injury), and dyslipidemia [19].