For example, Al-Fadly et al. reported Tetrahydroacridine-triazole (1, Figure 1) and thiosemicarbazide (2) hybrids as COX-2, 15-Lipooxygenase (LOX) hBChE, and hAChE inhibitors to serve as multi-target directed ligands for AD treatment [6]. The gene discussed is PTGS2; the disease is Alzheimer disease.