For example, Al-Fadly et al. reported Tetrahydroacridine-triazole (1, Figure 1) and thiosemicarbazide (2) hybrids as COX-2, 15-Lipooxygenase (LOX) hBChE, and hAChE inhibitors to serve as multi-target directed ligands for AD treatment [6]. This evidence concerns the gene LOX and Alzheimer disease.