For instance, scutellarin was found to disrupt tumor-associated angiogenesis by reducing transcription factor AP-1, while chrysin contained remarkable anti-angiogenesis properties through inhibiting VEGF/VEGFR2 expression and the phosphorylation of factors, e.g., JAK1 and STAT3 in HUVECs [31,32,33]. The gene discussed is JAK1; the disease is neoplasm.