TP53 and colon adenocarcinoma: Furthermore, the methanolic extract of P. dulce promoted cell death by apoptosis in human colon adenocarcinoma cells (SW480), demonstrating cell cycle arrest in the G1 phase, suggesting that the polyphenolic compounds of P. dulce interfere with the DNA synthesis process, in the activation of Tp53 (tumor suppressor) and in the regulation of cell death by apoptosis.