INS and type 1 diabetes mellitus: However, in insulin-containing islets of children with recent-onset T1D, a large proportion of insulin+ β-cells demonstrated various degrees of degranulation (Figure 7), and these islets had highly variable proportions of insulin+ and glucagon+/insulin+ cells—from islets with a predominance of insulin+ cells (Figure 7a) to islets with approximately equal proportions of insulin+ and glucagon+/insulin+ cells (Figure 7b), and islets with a predominance of glucagon+/insulin+ (Figure 7c).