Consequently, in human papillomavirus (HPV)-induced cervical cancer, two major viral oncogenes/oncoproteins, HPV E6 and E7, are able to destabilize tumor suppressors p53 and retinoblastoma protein (RB), inducing all hallmarks of cancer, mainly blocking apoptosis and initiating cell division, which result in tumor formation [263,264]. This evidence concerns the gene RB1 and neoplasm.