FASN cytoplasmic degradation can be prevented by autoubiquitination and degradation of enhanced F-box and WD repeat domain-containing 7β (FBXW7β), a cytoplasmic isoform of FBXW7 component of ubiquitin E3 ligase complex involved in FBXW7β/GSK3β-mediated FASN ubiquitination, resulting in FASN-mediated lipogenesis and promotion of colorectal cancer growth [168]. This evidence concerns the gene FASN and colorectal cancer.