CASP8 and neoplasm: Thus, caspase 8 is phosphorylated at Tyr380 by Src kinase upon EGF receptor stimulation, which suppresses apoptosis and participates in tumor progression [153], while pro-caspase 8 can be phosphorylated at Ser387 by pERK1/2 in a cell cycle specific manner, also inhibiting caspase 8 induced apoptosis in ovarian and BC cell lines [154].