PTEN and cancer: The tumor-suppressor PTEN, a phosphatidylinositol-3,4,5-triphosphate phospholipid phosphatase that catalyzes the dephosphorylation of phosphatidylinositol 3,4,5-triphosphate (PIP3) to phosphatidylinositol 4,5-diphosphate (PIP2) into the plasma membrane, is important for cell growth signaling, being usually mutated or silenced in cancer cells [86].