In addition, it was demonstrated that changes in CD44 glycosylation regulate its binding to hyaluronic acid, fibronectin, collagen, and podoplanin, and modulates c-Src/STAT3/TWIST1, PI3K/AKT/mTOR, ERK/NF-kB/NANOG and other signaling pathways, modulating TME traits and tumor cells behavior [69]. This evidence concerns the gene STAT3 and neoplasm.