Receptor tyrosine kinases (RTKs), including EGFR, VEGFR, PDGFR, and FGFR, regulate key processes such as proliferation, angiogenesis, and metastasis in cancers like non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and breast cancer [38]. The gene discussed is PDGFRB; the disease is breast carcinoma.