These downstream modifications in cellular signaling and genetic pathways by Nrf2 likely lead to alterations in the APOE2 gene, the most commonly associated gene with the apolipoprotein linked to the risk of earlier onset of the disease [108], as well as in the genes coding for APP, Presenilin 1 (PSEN1), and Presenilin 2 (PSEN2), which lead to excessive production of Aβ [49], mitigating complications and poor prognosis associated with AD. Here, PSEN2 is linked to Alzheimer disease.