For example, in ovarian cancer cells, lovastatin 20 μM for 24 h induced cell apoptosis by blocking HMG-CoA reductase activity, whereas cytotoxicity was observed in lung cancer cells after exposure to Lov 10 μM for 72 h by increasing p21WAF and/or p27KIP, and decreasing cyclin D1 which are cell-cycle checkpoint regulators [32,33]. This evidence concerns the gene CCND1 and ovarian cancer.