Ameliorate infarction, neurological deficit scores, and spatial memory deficits after cerebral ischemia↓ Neuron loss and ↑ neurogenesis after ischemic stroke↓ Apoptosis by regulating apoptotic-related proteins↓ Glial activation ↑ AMPK and IκBα activation↓ Akt, NFκB p65, ERK, JNK, and p38. Here, AKT1 is linked to ischemic stroke.