Many of the genes, E2F6, TLR2, SFRP2, PIK3R1, EYA4, THBS2, ELMO1, RELN, GAS1, FZD4, KLF12, TDP1, SCG5, CDH13, and TCF4, have been published in relation to cancer more than 50 times, and some have been published in hundreds or even thousands of publications in relation to cancer and/or CRC (Table 2). The gene discussed is FZD4; the disease is cancer.